modafinil will minimize the extent or outcome of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Sure, I’m below has Individually examined all of these dosages. This ain’t hypothetical pimpin’ and pandering. I’m talking on knowledge in this article, together with the countless e-mails from preceding buyers commenting on dosing.
In vitro measurements show that sixty% of modafinil is bound to plasma proteins at scientific concentrations in the drug. This proportion modifications very little if the concentration of modafinil is varied.[146]
levoketoconazole will boost the stage or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Psychiatric Conditions: Modafinil should be made use of with caution in clients by using a historical past of psychosis and/or mania. This kind of people need to be monitored for hallucinations, delusions, mania, aggression, and suicidal ideation upon starting modafinil. Discontinuation is suggested if these symptoms create.
It is against the law to import modafinil to The us with out a Drug Enforcement Administration (DEA)-registered importer as well as a prescription.[204] People today may perhaps lawfully deliver modafinil in the US from a international nation for personal use, limited to 50 dosage units, by using a prescription and correct declaration for the border.
Steer clear of or substitute A further drug for these drugs when possible. Consider for lack of therapeutic impact if medication need to be coadministered. Regulate dose As outlined by prescribing information if wanted.
Steer clear of concomitant use of tucatinib with CYP3A substrates, where small concentration changes may perhaps produce significant or lifestyle-threatening toxicities. If unavoidable, decrease CYP3A substrate dose according to merchandise here labeling.
apalutamide will reduce the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication which might be CYP3A4 substrates may result in lower exposure to these prescription drugs.
Any dose that may be 50 mg or less is taken into account a microdose— which means the dose is below the therapeutic threshold.
elvitegravir/cobicistat/emtricitabine/tenofovir DF improves amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
It is far from recognised irrespective of whether this medicine will damage an unborn little one. Notify your health care provider In case you are pregnant or plan to be pregnant.
primidone will minimize the extent or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
From postmarketing practical experience, there are stories of deadly overdoses involving modafinil on your own or together with other prescription drugs. Signs or symptoms most often accompanying PROVIGIL